The Beautiful Cure

The Beautiful Cure: “Visceral.”—Wall Street Journal     “Illuminating.”—Publishers Weekly     “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that li...

Immunization

Immunization: As the world pins its hope for the end of the coronavirus pandemic to the successful rollout of vaccines, this book offers a vital long view of such efforts—and our resistance to them.   At a time when vaccines are a vital tool in the fight against COVID-19 in all its various mutations, this hard-hitting book takes a longer historical perspective. It argues that globalization and cuts to healthcare have been eroding faith in the institutions producing and providing vaccines for more than thirty years. It tells the history of immunization from the work of early pioneers such as Louis Pasteur and Robert Koch through the eradication of smallpox in 1980, to the recent introduction of new kinds of genetically engineered vaccines. Immunization exposes the limits of public health authorities while suggesting how they can restore our confidence. Public health experts and all those considering vaccinations should read this timely history.

Breathing

Breathing: Our knowledge of breathing has shaped our social history and philosophical beliefs since prehistory. Breathing occupied a spiritual status for the ancients, while today it is central to the practice of many forms of meditation, like Yoga. Over time physicians, scientists, and engineers have pieced together the intricate biological mechanisms of breathing to devise ever more sophisticated devices to support and maintain breathing indefinitely, from iron lungs to the modern ventilator. Breathing supplementary oxygen has allowed us to conquer Everest, travel to the Moon, and dive to ever greater ocean depths. We all expect to breathe fresh and clean air, but with an increase in air pollution that expectation is no longer being met. Today, respiratory viruses like COVID-19 are causing disasters both human and economical on a global scale. This is the story of breathing—a tale relevant to everyone.

Viral Economies

Viral Economies: Over the last decade, infectious disease outbreaks have heightened fears of a catastrophic pandemic passing from animals to humans. From Ebola and bird flu to swine flu and MERS, zoonotic viruses are killing animals and wreaking havoc on the people living near them. Given this clear correlation between animals and viral infection, why are animals largely invisible in social science accounts of pandemics, and why do they remain marginal in critiques of global public health?   In Viral Economies, Natalie Porter draws from long-term research on bird flu in Vietnam to chart the pathways of scientists, NGO workers, state veterinarians, and poultry farmers as they define and address pandemic risks. Porter argues that as global health programs expand their purview to include life and livestock, they weigh the interests of public health against those of commercial agriculture, rural tradition, and scientific innovation. Porter challenges human-centered analyses of pandemics and shows how dynamic and often dangerous human-animal relations take on global significance as poultry and their pathogens travel through global livestock economies and transnational health networks. Viral Economies urges readers to think critically about the ideas, relationships, and practices that produce our everyday commodities, and that shape how we determine the value of life—both human and nonhuman.

Big Med

Big Med: There is little debate that health care in the United States is in need of reform. But where should those improvements begin? With insurers? Drug makers? The doctors themselves? In Big Med, David Dranove and Lawton Robert Burns argue that we’re overlooking the most ubiquitous cause of our costly and underperforming system: megaproviders, the expansive health care organizations that have become the face of American medicine. Your local hospital is likely part of one. Your doctors, too. And the megaproviders are bad news for your health and your wallet. Drawing on decades of combined expertise in health care consolidation, Dranove and Burns trace Big Med’s emergence in the 1990s, followed by its swift rise amid false promises of scale economies and organizational collaboration. In the decades since, megaproviders have gobbled up market share and turned independent physicians into salaried employees of big bureaucracies, while delivering on none of their early promises. For patients this means higher costs and lesser care. Meanwhile, physicians report increasingly low morale, making it all but impossible for most systems to implement meaningful reforms. In Big Med, Dranove and Burns combine their respective skills in economics and management to provide a nuanced explanation of how the provision of health care has been corrupted and submerged under consolidation. They offer practical recommendations for improving competition policies that would reform megaproviders to actually ach...

A Planet of Viruses

A Planet of Viruses: In 2020, an invisible germ—a virus—wholly upended our lives. We’re most familiar with the viruses that give us colds or Covid-19. But viruses also cause a vast range of other diseases, including one disorder that makes people sprout branch-like growths as if they were trees. Viruses have been a part of our lives for so long that we are actually part virus: the human genome contains more DNA from viruses than our own genes. Meanwhile, scientists are discovering viruses everywhere they look: in the soil, in the ocean, even in deep caves miles underground.   Fully revised and updated, with new illustrations and a new chapter about coronaviruses and the spread of Covid-19, this third edition of Carl Zimmer’s A Planet of Viruses pulls back the veil on this hidden world. It presents the latest research on how viruses hold sway over our lives and our biosphere, how viruses helped give rise to the first life-forms, how viruses are producing new diseases, how we can harness viruses for our own ends, and how viruses will continue to control our fate as long as life endures.

How to Make a Vaccine

How to Make a Vaccine: Distinguished expert in vaccine development John Rhodes tells the story of the first approved COVID-19 vaccines and offers an essential, up-to-the-minute primer on how scientists discover, test, and distribute vaccines. As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been—when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time.  In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment—and will lead to multiple COVID-19 vaccines. Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the imm...

Gathering Medicines

Gathering Medicines: In the early 2000s, the central government of China encouraged all of the nation’s registered minorities to “salvage, sort, synthesize, and elevate” folk medical knowledges in an effort to create local health care systems comparable to the nationally supported institutions of traditional Chinese medicine. Gathering Medicines bears witness to this remarkable moment of knowledge development while sympathetically introducing the myriad therapeutic traditions of southern China.   Over a period of six years, Judith Farquhar and Lili Lai worked with seven minority nationality groups in China’s southern mountains, observing how medicines were gathered and local healing systems codified. Gathering Medicines shares their intimate view of how people understand ethnicity, locality, the body, and nature. This ethnography of knowledge diversities in multiethnic China is a testament to the rural wisdom of mountain healers, one that theorizes, from the ground up, the dynamic encounters between formal statist knowledge and the popular authority of the wild.

The Poison Trials

The Poison Trials: In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.

Epidemic Empire

Epidemic Empire: Terrorism is a cancer, an infection, an epidemic, a plague. For more than a century, this metaphor has figured insurgent violence as contagion in order to contain its political energies. In Epidemic Empire, Anjuli Fatima Raza Kolb shows that this trope began in responses to the Indian Mutiny of 1857 and tracks its tenacious hold through 9/11 and beyond. The result is the first book-length study to approach the global War on Terror from a postcolonial literary perspective. Raza Kolb assembles a diverse archive from colonial India, imperial Britain, French and independent Algeria, the postcolonial Islamic diaspora, and the neoimperial United States. Anchoring her book are studies of four major writers in the colonial-postcolonial canon: Rudyard Kipling, Bram Stoker, Albert Camus, and Salman Rushdie. Across these sources, she reveals the tendency to imagine anticolonial rebellion, and Muslim insurgency specifically, as a virulent form of social contagion. Exposing the long history of this broken but persistent narrative, Epidemic Empire is a major contribution to the rhetorical history of our present moment.

Science in the Forest, Science in the Past

Science in the Forest, Science in the Past: This collection brings together leading anthropologists, historians, philosophers, and artificial-intelligence researchers to discuss the sciences and mathematics used in various Eastern, Western, and Indigenous societies, both ancient and contemporary. The authors analyze prevailing assumptions about these societies and propose more faithful, sensitive analyses of their ontological views about reality—a step toward mutual understanding and translatability across cultures and research fields. Science in the Forest, Science in the Past is a pioneering interdisciplinary exploration that will challenge the way readers interested in sciences, mathematics, humanities, social research, computer sciences, and education think about deeply held notions of what constitutes reality, how it is apprehended, and how to investigate it.

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Why Study Biology by the Sea?

Why Study Biology by the Sea?: For almost a century and a half, biologists have gone to the seashore to study life. The oceans contain rich biodiversity, and organisms at the intersection of sea and shore provide a plentiful sampling for research into a variety of questions at the laboratory bench: How does life develop and how does it function? How are organisms that look different related, and what role does the environment play? From the Stazione Zoologica in Naples to the Marine Biological Laboratory in Woods Hole, the Amoy Station in China, or the Misaki Station in Japan, students and researchers at seaside research stations have long visited the ocean to investigate life at all stages of development and to convene discussions of biological discoveries. Exploring the history and current reasons for study by the sea, this book examines key people, institutions, research projects, organisms selected for study, and competing theories and interpretations of discoveries, and it considers different ways of understanding research, such as through research repertoires. A celebration of coastal marine research, Why Study Biology by the Sea? reveals why scientists have moved from the beach to the lab bench and back.

Patterns in Nature

Patterns in Nature: Though at first glance the natural world may appear overwhelming in its diversity and complexity, there are regularities running through it, from the hexagons of a honeycomb to the spirals of a seashell and the branching veins of a leaf. Revealing the order at the foundation of the seemingly chaotic natural world, Patterns in Nature explores not only the math and science but also the beauty and artistry behind nature’s awe-inspiring designs. Unlike the patterns we create in technology, architecture, and art, natural patterns are formed spontaneously from the forces that act in the physical world. Very often the same types of pattern and form – spirals, stripes, branches, and fractals, say—recur in places that seem to have nothing in common, as when the markings of a zebra mimic the ripples in windblown sand. That’s because, as Patterns in Nature shows, at the most basic level these patterns can often be described using the same mathematical and physical principles: there is a surprising underlying unity in the kaleidoscope of the natural world. Richly illustrated with 250 color photographs and anchored by accessible and insightful chapters by esteemed science writer Philip Ball, Patterns in Nature reveals the organization at work in vast and ancient forests, powerful rivers, massing clouds, and coastlines carved out by the sea.   By exploring similarities such as those between a snail shell and the swirling stars of a galaxy, or t...

The Beautiful Cure

The Beautiful Cure: “Visceral.”—Wall Street Journal     “Illuminating.”—Publishers Weekly     “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that li...

Plague Years

Plague Years: In 1992, Dr. Ross A. Slotten signed more death certificates in Chicago—and, by inference, the state of Illinois—than anyone else. As a family physician, he was trained to care for patients from birth to death, but when he completed his residency in 1984, he had no idea that many of his future patients would be cut down in the prime of their lives. Among those patients were friends, colleagues, and lovers, shunned by most of the medical community because they were gay and HIV positive. Slotten wasn’t an infectious disease specialist, but because of his unique position as both a gay man and a young physician, he became an unlikely pioneer, swept up in one of the worst epidemics in modern history.

Plague Years is an unprecedented first-person account of that epidemic, spanning not just the city of Chicago but four continents as well. Slotten provides an intimate yet comprehensive view of the disease’s spread alongside heartfelt portraits of his patients and his own conflicted feelings as a medical professional, drawn from more than thirty years of personal notebooks. In telling the story of someone who was as much a potential patient as a doctor, Plague Years sheds light on the darkest hours in the history of the LGBT community in ways that no previous medical memoir has.

Merchants of Medicines

Merchants of Medicines: The period from the late seventeenth to the early nineteenth century—the so-called long eighteenth century of English history—was a time of profound global change, marked by the expansion of intercontinental empires, long-distance trade, and human enslavement. It was also the moment when medicines, previously produced locally and in small batches, became global products. As greater numbers of British subjects struggled to survive overseas, more medicines than ever were manufactured and exported to help them. Most historical accounts, however, obscure the medicine trade’s dependence on slave labor, plantation agriculture, and colonial warfare.

In Merchants of Medicines, Zachary Dorner follows the earliest industrial pharmaceuticals from their manufacture in the United Kingdom, across trade routes, and to the edges of empire, telling a story of what medicines were, what they did, and what they meant. He brings to life business, medical, and government records to evoke a vibrant early modern world of London laboratories, Caribbean estates, South Asian factories, New England timber camps, and ships at sea. In these settings, medicines were produced, distributed, and consumed in new ways to help confront challenges of distance, labor, and authority in colonial territories. Merchants of Medicines offers a new history of economic and medical development across early America, Britain, and South Asia, revealing the unsettlingly close ties among medicine, finance,...

Medical Monopoly

Medical Monopoly: During most of the nineteenth century, physicians and pharmacists alike considered medical patenting and the use of trademarks by drug manufacturers unethical forms of monopoly; physicians who prescribed patented drugs could be, and were, ostracized from the medical community. In the decades following the Civil War, however, complex changes in patent and trademark law intersected with the changing sensibilities of both physicians and pharmacists to make intellectual property rights in drug manufacturing scientifically and ethically legitimate. By World War I, patented and trademarked drugs had become essential to the practice of good medicine, aiding in the rise of the American pharmaceutical industry and forever altering the course of medicine.             Drawing on a wealth of previously unused archival material, Medical Monopoly combines legal, medical, and business history to offer a sweeping new interpretation of the origins of the complex and often troubling relationship between the pharmaceutical industry and medical practice today. Joseph M. Gabriel provides the first detailed history of patent and trademark law as it relates to the nineteenth-century pharmaceutical industry as well as a unique interpretation of medical ethics, therapeutic reform, and the efforts to regulate the market in pharmaceuticals before World War I. His book will be of interest not only to historians of medicine and science and intellectual property scholars but also to anyo...

Heredity under the Microscope

Heredity under the Microscope: By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms.
 
Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.

Make Labs’ Biosphere

Make Labs’ Biosphere